| Authors | Leu, YL; Hwang, TL; Kuo, PC; Liou, KP; Huang, BS; Chen, GF |
| Author Full Name | Leu, Yann-Lii; Hwang, Tsong-Long; Kuo, Ping-Chung; Liou, Kun-Pei; Huang, Bow-Shin; Chen, Guo-Feng |
| Title | Constituents from Vigna vexillata and Their Anti-Inflammatory Activity |
| Source | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| Language | English |
| Document Type | Article |
| Author Keywords | Vigna; isoflavone; anti-inflammatory; superoxide anion; elastase |
| Keywords Plus | HOT-WATER EXTRACT; CHEMICAL-CONSTITUENTS; AZUKI-BEANS; ANGULARIS; NEUTROPHILS; LEAVES; CELLS; RATS; GENISTEIN; STEROIDS |
| Abstract | The seeds of Vigna genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of V. vexillata demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of V. vexillata. One new sterol (1) and two new isoflavones (2,3) were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23), abscisic acid (25), and quercetin (40) displayed the most significant inhibition of superoxide anion generation and elastase release. |
| Author Address | [Kuo, Ping-Chung; Liou, Kun-Pei; Huang, Bow-Shin] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan; [Leu, Yann-Lii; Hwang, Tsong-Long] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan; [Leu, Yann-Lii; Hwang, Tsong-Long] Chang Gung Univ, Chinese Herbal Med Res Team, Hlth Aging Res Ctr, Tao Yuan 333, Taiwan; [Chen, Guo-Feng] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan |
| Reprint Address | Kuo, PC (corresponding author), Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan. |
| E-mail Address | ylleu@mail.cgu.edu.tw; htl@mail.cgu.edu.tw; pcckuoo@sunws.nfu.edu.tw; pcckuoo@sunws.nfu.edu.tw; brues0923@yahoo.com.tw; dolphineddie@yahoo.com.tw |
| ResearcherID Number | Hwang, Tsong-Long/AAE-6944-2020 |
| ORCID Number | Hwang, Tsong-Long/0000-0002-5780-3977 |
| Funding Agency and Grant Number | National Science Council, Taiwan, ROCMinistry of Science and Technology, Taiwan |
| Funding Text | The authors are thankful to the National Science Council, Taiwan, ROC, for financial support of the present research. We also thank J. R. Wu, National Cheng Kung University, for recording the NMR spectra. |
| Times Cited | 14 |
| Total Times Cited Count (WoS, BCI, and CSCD) | 16 |
| Publisher | MDPI |
| Publisher City | BASEL |
| Publisher Address | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND |
| ISSN | 1661-6596 |
| 29-Character Source Abbreviation | INT J MOL SCI |
| ISO Source Abbreviation | Int. J. Mol. Sci. |
| Publication Date | AUG |
| Year Published | 2012 |
| Volume | 13 |
| Issue | 8 |
| Beginning Page | 9754 |
| Ending Page | 9768 |
| Digital Object Identifier (DOI) | 10.3390/ijms13089754 |
| Page Count | 15 |
| Web of Science Category | Biochemistry & Molecular Biology; Chemistry, Multidisciplinary |
| Subject Category | Biochemistry & Molecular Biology; Chemistry |
| Document Delivery Number | 998MK |
| Unique Article Identifier | WOS:000308243400025 |
