| Publication Type | J |
| Authors | Simlai, Aritra; Gangwar, Anjali; Ghonge, Sarthaki Avinash; Roy, Amit |
| Author Full Name | Simlai, Aritra; Gangwar, Anjali; Ghonge, Sarthaki Avinash; Roy, Amit |
| Title | Antimicrobial and Antioxidative Activities in the Stem Extracts of Derris trifoliata, a Mangrove Shrub |
| Source | BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH |
| Language | English |
| Document Type | Article |
| Author Keywords | Derris trifoliata; phytochemical; antimicrobial activity; antioxidant; mangrove plants; TLC-bioautography |
| Keywords Plus | IN-VITRO EVALUATION; LEAFY VEGETABLES; HUMAN HEALTH; PLANT; FLAVONOIDS; PATHOGENS; INDIA; BARK |
| Abstract | Aims: An in-depth study on the phytochemical contents, antimicrobial and antioxidative activities of stem tissue of Derris trifoliata Lour. (Fabaceae), a mangrove shrub from Sundarban estuary, India. Methodology: Phytochemical analyses were carried out using established methods for quantitative determination of phenolics, flavonoids, tannins, alkaloids and saponins. Antimicrobial potential of various extracts of D. trifoliata were evaluated by disc diffusion technique against two Gram-positive (Bacillus subtilis and Bacillus coagulans), two Gram-negative (Escherichia coli and Proteus vulgaris) bacteria and one fungus (Saccharomyces cerevisiae). The antioxidative efficacy was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The tissue extracts were subjected to thin layer chromatography (TLC) separation and the fractions with antimicrobial and antioxidative properties were identified using TLC-bioautography. Results: Phytochemical analyses showed the presence of appreciable amount of phenolics, flavonoids and alkaloids. All the extracts have shown activity against B. subtilis and B. coagulans, among which the methanolic has been found to be most effective. The antimicrobial activities of the extracts were found to be stable despite drastic pH and thermal treatments. The antioxidative property was also found to be quite appreciable and was considerably stable after thermal treatments. A number of the phytochemical fractions were found to possess antimicrobial/antioxidative properties when subjected to TLC-bioautography. Conclusion: The study suggests Derris trifoliata stem as a potential source of bioactive compounds with stable antimicrobial and antioxidative properties and can be used as natural antimicrobial/antioxidative agents in clinical, pharmaceutical and food processing industries. |
| Author Address | [Simlai, Aritra; Gangwar, Anjali; Ghonge, Sarthaki Avinash; Roy, Amit] Visva Bharati Univ, Dept Biotechnol, Santini Ketan 731235, W Bengal, India; [Simlai, Aritra] Univ Hyderabad, Dept Biochem, Hyderabad 500046, Telangana, India |
| Reprint Address | Roy, A (reprint author), Visva Bharati Univ, Dept Biotechnol, Santini Ketan 731235, W Bengal, India. |
| E-mail Address | amit.roy@visva-bharati.ac.in |
| ResearcherID Number | Roy, Amit/AAU-9746-2020 |
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| Cited Reference Count | 44 |
| Times Cited | 0 |
| Total Times Cited Count (WoS, BCI, and CSCD) | 0 |
| Publisher | SCIENCEDOMAIN INT |
| Publisher City | GURGAON |
| Publisher Address | SCIENCEDOMAIN INT, GURGAON, 00000, INDIA |
| ISSN | 2231-2919 |
| 29-Character Source Abbreviation | BRIT J PHARM RES |
| ISO Source Abbreviation | Brit. J. Pharm. Res. |
| Year Published | 2017 |
| Volume | 17 |
| Issue | 3 |
| Article Number | ARTN 34455 |
| Digital Object Identifier (DOI) | 10.9734/JPRI/2017/34455 |
| Subject Category | Pharmacology & Pharmacy |
| Unique Article Identifier | WOS:000411506900005 |
